Transancestral mapping and genetic load in systemic lupus erythematosus

D. Langefeld, Carl; C. Ainsworth, Hannah; S. Cunninghame Graham, Deborah; A. Kelly, Jennifer; E. Comeau, Mary; C. Marion, Miranda; D. Howard, Timothy; S. Ramos, Paula; A. Croker, Jennifer; L. Morris, David; K. Sandling, Johanna; Carlsson Almlöf, Jonas; M. Acevedo-Vásquez, Eduardo; S. Alarcón, Graciela; M. Babini, Alejandra; Baca, Vicente; A. Bengtsson, Anders; A. Berbotto, Guillermo; Bijl, Marc; E. Brown, Elizabeth; I. Brunner, Hermine; H. Cardiel, Mario; Catoggio, Luis; Cervera, Ricard; M. Cucho-Venegas, Jorge; Rantapää Dahlqvist, Solbritt; D’Alfonso, Sandra; Martins Da Silva, Berta; de la Rúa Figueroa, Iñigo; Doria, Andrea; C. Edberg, Jeffrey; Endreffy, Emőke; A. Esquivel-Valerio, Jorge; R. Fortin, Paul; I. Freedman, Barry; Frostegård, Johan; A. García, Mercedes; García de la Torre, Ignacio; S. Gilkeson, Gary; D. Gladman, Dafna; Gunnarsson, Iva; M. Guthridge, Joel; L. Huggins, Jennifer; A. James, Judith; G. M. Kallenberg, Cees; L. Kamen, Diane; R. Karp, David; M. Kaufman, Kenneth; C. Kottyan, Leah; Kovács, László; Laustrup, Helle; R. Lauwerys, Bernard; Li, Quan-Zhen; A. Maradiaga-Ceceña, Marco; Martín, Javier; M. McCune, Joseph; R. McWilliams, David; T. Merrill, Joan; Miranda, Pedro; F. Moctezuma, José; K. Nath, Swapan; B. Niewold, Timothy; Orozco, Lorena; Ortego-Centeno, Norberto; Petri, Michelle; A. Pineau, Christian; A. Pons-Estel, Bernardo; Pope, Janet; Raj, Prithvi; Ramsey-Goldman, Rosalind; D. Reveille, John; P. Russell, Laurie; M. Sabio, José; A. Aguilar-Salinas, Carlos; R. Scherbarth, Hugo; Scorza, Raffaella; F. Seldin, Michael; Sjöwall, Christopher; Svenungsson, Elisabet; D. Thompson, Susan; M. A. Toloza, Sergio; Truedsson, Lennart; Tusié-Luna, Teresa; Vasconcelos, Carlos; M. Vilá, Luis; J. Wallace, Daniel; H. Weisman, Michael; E. Wither, Joan; Bhangale, Tushar; R. Oksenberg, Jorge; D. Rioux, John; K. Gregersen, Peter; Syvänen, Ann-Christine; Rönnblom, Lars; A. Criswell, Lindsey; O. Jacob, Chaim; L. Sivils, Kathy; P. Tsao, Betty; E. Schanberg, Laura; W. Behrens, Timothy; D. Silverman, Earl; E. Alarcón-Riquelme, Marta; P. Kimberly, Robert; B. Harley, John; K. Wakeland, Edward; R. Graham, Robert; M. Gaffney, Patrick; J. Vyse, Timothy

doi:10.1038/ncomms16021

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Transancestral mapping and genetic load in systemic lupus erythematosus

Shared by NobleBlocks on Jul 17, 2017 • 12:00 AM UTC

Authors:

Carl D. Langefeld

Hannah C. Ainsworth

Deborah S. Cunninghame Graham

Abstract

Abstract Systemic lupus erythematosus (SLE) is an autoimmune disease with marked gender and ethnic disparities. We report a large transancestral association study of SLE using Immunochip genotype data from 27,574 individuals of European (EA), African (AA) and Hispanic Amerindian (HA) ancestry. We id...

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