Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

Kamal, Maud; Lameiras, Sonia; Deloger, Marc; Morel, Adeline; Vacher, Sophie; Lecerf, Charlotte; Dupain, Célia; Jeannot, Emmanuelle; Girard, Elodie; Baulande, Sylvain; Dubot, Coraline; Kenter, Gemma; S. Jordanova, Ekaterina; M. J. J. Berns, Els; Bataillon, Guillaume; Popovic, Marina; Rouzier, Roman; Cacheux, Wulfran; Le Tourneau, Christophe; Nicolas, Alain; Servant, Nicolas; M. Scholl, Suzy; Bièche, Ivan; Consortium, RAIDs; de la Rochefordiere, Anne; Fumoleau, Pierre; Mandic, Aljosa; Samet, Nina; Kamoun, Choumouss; Rondoff, Windy; Armanet, Sebastien; Rohel, Alexandra; Neffati, Souhir; Legrier, Marie-Emmanuelle; Ngoumou Mabiala, Sinette; Dureau, Sylvain; Errera, Coralie; Craina, Marius; Margan, Madalin; Samuels, Sanne; Zijlmans, Henry; Hillemanns, Peter; Dema, Sorin; Dema, Alis; Malenkovic, Goran; Djuran, Branislav; Floquet, Anne; Guyon, Frédéric; Emmanuel Colombo, Pierre; Fabbro, Michel; Kerr, Christine; Ngo, Charlotte; Lecuru, Fabrice; Rivin del Campo, Eleonor; Coutant, Charles; Marchal, Frédéric; Mesgouez-Nebout, Nathalie; Fourchotte, Virginie; Guillaume Feron, Jean; Morice, Philippe; Deutsch, Eric; Wimberger, Pauline; Classe, Jean-Marc; von der Leyen, Heiko; Minsat, Mathieu; Nagy, Istvan; Balint, Balazs; de Saint-Jorre, Nicolas; Savignoni, Alexia; Perez, Franck; Tresca, Patricia; Gleeson, Noreen; Hupe, Philippe; Roman Roman, Sergio; Barillot, Emmanuel; Coffin, Fanny; Nuijen, Bastiaan; Boissonnas, Alexandre; Billaud, Marc; Lafanechere, Laurence; Verweij, Jaap; Bandel, Arjan; Hellemann, Jozien; Ruigrok-Ritstier, Kirsten; Harter, Philipp; Kurzeder, Christian; Mustea, Alexander; Banu, Eugeniu; Patcas, Elisabeta; Cernat, Victor; Slocker, Andrea; Mondini, Michele; Bossard, Maud; Chupin, Julie; Rodenhuis, Sjoerd; Medema, Rene; Havemeier, Anika; Fink, Thomas; Michon, Amelie; Kubiak, Christine; Beaufort, Corine; Cseklye, Judit; Latinovics, Dora; Bihari, Peter; Brito, Isabel; Ouine, Bérengère; De Koning, Leanne; Puard, Vincent; Del Nery, Elaine; Beijnen, Jos; Koensgen, Dominique; Bruennert, Daniela; Lucic, Milos; ter Haar, Natalja

doi:10.1038/s41416-020-01153-4

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Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site

Shared by NobleBlocks on Nov 16, 2020 • 12:00 AM UTC

Authors:

Maud Kamal

Sonia Lameiras

Marc Deloger

Abstract

Abstract Background Cervical cancer (CC) remains a leading cause of gynaecological cancer-related mortality with infection by human papilloma virus (HPV) being the most important risk factor. We analysed the association between different viral integration signatures, clinical parameters and outcome ...

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