Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Stremmel, Christopher; Schuchert, R.; Wagner, Franziska; Thaler, Raffael; Weinberger, Tobias; Pick, Robert; Mass, Elvira; Ishikawa‐Ankerhold, Hellen; Margraf, Andreas; Hutter, Sonja; J. Vagnozzi, Ronald; Klapproth, Sarah; Frampton, Jon; Yona, Simon; Scheiermann, Christoph; D. Molkentin, Jeffery; Jeschke, Udo; Moser, Markus; Sperandio, Markus; Maßberg, Steffen; Geissmann, Frédéric; Schulz, Christian

doi:10.1038/s41467-017-02492-2

Public

Yolk sac macrophage progenitors traffic to the embryo during defined stages of development

Published in Nature Communications • Jan 2, 2018

Authors:

Christopher Stremmel

R. Schuchert

Franziska Wagner

Abstract

Abstract Tissue macrophages in many adult organs originate from yolk sac (YS) progenitors, which invade the developing embryo and persist by means of local self-renewal. However, the route and characteristics of YS macrophage trafficking during embryogenesis are incompletely understood. Here we show...

Subject

Yolk sac

Cell biology

Progenitor cell

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