The repertoire of mutational signatures in human cancer

B. Alexandrov, Ludmil; Kim, Jaegil; J. Haradhvala, Nicholas; Ni Huang, Mi; Wei Tian Ng, Alvin; Wu, Yang; Boot, Arnoud; R. Covington, Kyle; A. Gordenin, Dmitry; N. Bergstrom, Erik; M. Ashiqul Islam, S.; Lopez-Bigas, Nuria; J. Klimczak, Leszek; R. McPherson, John; Morganella, Sandro; Sabarinathan, Radhakrishnan; A. Wheeler, David; Mustonen, Ville; Mutational Signatures Working Group, PCAWG; B. Alexandrov, Ludmil; N. Bergstrom, Erik; Boot, Arnoud; Boutros, Paul; Chan, Kin; R. Covington, Kyle; Fujimoto, Akihiro; Getz, Gad; A. Gordenin, Dmitry; J. Haradhvala, Nicholas; Ni Huang, Mi; M. Ashiqul Islam, S.; Kazanov, Marat; Kim, Jaegil; J. Klimczak, Leszek; Lopez-Bigas, Nuria; Lawrence, Michael; Martincorena, Iñigo; R. McPherson, John; Morganella, Sandro; Mustonen, Ville; Nakagawa, Hidewaki; Wei Tian Ng, Alvin; Polak, Paz; Prokopec, Stephenie; A. Roberts, Steven; G. Rozen, Steven; Sabarinathan, Radhakrishnan; Saini, Natalie; Shibata, Tatsuhiro; Shiraishi, Yuichi; R. Stratton, Michael; Tean Teh, Bin; Vázquez-García, Ignacio; A. Wheeler, David; Wu, Yang; Yousif, Fouad; Yu, Willie; Getz, Gad; G. Rozen, Steven; R. Stratton, Michael; Consortium, PCAWG; A. Aaltonen, Lauri; Abascal, Federico; Abeshouse, Adam; Aburatani, Hiroyuki; J. Adams, David; Agrawal, Nishant; Soo Ahn, Keun; Ahn, Sung-Min; Aikata, Hiroshi; Akbani, Rehan; C. Akdemir, Kadir; Al-Ahmadie, Hikmat; T. Al-Sedairy, Sultan; Al-Shahrour, Fatima; Alawi, Malik; Albert, Monique; Aldape, Kenneth; B. Alexandrov, Ludmil; Ally, Adrian; Alsop, Kathryn; G. Alvarez, Eva; Amary, Fernanda; B. Amin, Samirkumar; Aminou, Brice; Ammerpohl, Ole; J. Anderson, Matthew; Ang, Yeng; Antonello, Davide; Anur, Pavana; Aparicio, Samuel; L. Appelbaum, Elizabeth; Arai, Yasuhito; Aretz, Axel; Arihiro, Koji; Ariizumi, Shun-ichi; Armenia, Joshua; Arnould, Laurent; Asa, Sylvia; Assenov, Yassen; Atwal, Gurnit; Aukema, Sietse; Todd Auman, J.; R. R. Aure, Miriam; Awadalla, Philip; Aymerich, Marta; D. Bader, Gary; Baez-Ortega, Adrian; H. Bailey, Matthew; J. Bailey, Peter; Balasundaram, Miruna; Balu, Saianand; Bandopadhayay, Pratiti; E. Banks, Rosamonde; Barbi, Stefano; P. Barbour, Andrew; Barenboim, Jonathan; Barnholtz-Sloan, Jill; Barr, Hugh; Barrera, Elisabet; Bartlett, John; Bartolome, Javier; Bassi, Claudio; F. Bathe, Oliver; Baumhoer, Daniel; Bavi, Prashant; B. Baylin, Stephen; Bazant, Wojciech; Beardsmore, Duncan; A. Beck, Timothy; Behjati, Sam; Behren, Andreas; Niu, Beifang; Bell, Cindy; Beltran, Sergi; Benz, Christopher; Berchuck, Andrew; K. Bergmann, Anke; N. Bergstrom, Erik; P. Berman, Benjamin; M. Berney, Daniel; H. Bernhart, Stephan; Beroukhim, Rameen; Berrios, Mario; Bersani, Samantha; Bertl, Johanna; Betancourt, Miguel; Bhandari, Vinayak; G. Bhosle, Shriram; V. Biankin, Andrew; Bieg, Matthias; Bigner, Darell; Binder, Hans; Birney, Ewan; Birrer, Michael; K. Biswas, Nidhan; Bjerkehagen, Bodil; Bodenheimer, Tom; Boice, Lori; Bonizzato, Giada; S. De Bono, Johann; Boot, Arnoud; S. Bootwalla, Moiz; Borg, Ake; Borkhardt, Arndt; A. Boroevich, Keith; Borozan, Ivan; Borst, Christoph; Bosenberg, Marcus; Bosio, Mattia; Boultwood, Jacqueline; Bourque, Guillaume; C. Boutros, Paul; Steven Bova, G.; T. Bowen, David; Bowlby, Reanne; D. L. Bowtell, David; Boyault, Sandrine; Boyce, Rich; Boyd, Jeffrey; Brazma, Alvis; Brennan, Paul; S. Brewer, Daniel; B. Brinkman, Arie; G. Bristow, Robert; R. Broaddus, Russell; E. Brock, Jane; Brock, Malcolm; Broeks, Annegien; N. Brooks, Angela; Brooks, Denise; Brors, Benedikt; Brunak, Søren; J. C. Bruxner, Timothy; L. Bruzos, Alicia; Buchanan, Alex; Buchhalter, Ivo; Buchholz, Christiane; Bullman, Susan; Burke, Hazel

doi:10.1038/s41586-020-1943-3

Public

The repertoire of mutational signatures in human cancer

Shared by NobleBlocks on Feb 5, 2020 • 12:00 AM UTC

Authors:

Ludmil B. Alexandrov

Jaegil Kim

Nicholas J. Haradhvala

Abstract

Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 2 of the International Cancer Genome Consortium (ICGC) and The Canc...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!