Whole-genome sequencing reveals host factors underlying critical COVID-19

Kousathanas, Athanasios; Pairo-Castineira, Erola; Rawlik, Konrad; Stuckey, Alex; A. Odhams, Christopher; Walker, Susan; D. Russell, Clark; Malinauskas, Tomas; Wu, Yang; Millar, Jonathan; Shen, Xia; S. Elliott, Katherine; Griffiths, Fiona; Oosthuyzen, Wilna; Morrice, Kirstie; Keating, Sean; Wang, Bo; Rhodes, Daniel; Klaric, Lucija; Zechner, Marie; Parkinson, Nick; Siddiq, Afshan; Goddard, Peter; Donovan, Sally; Maslove, David; Nichol, Alistair; G. Semple, Malcolm; Zainy, Tala; Maleady-Crowe, Fiona; Todd, Linda; Salehi, Shahla; Knight, Julian; Elgar, Greg; Chan, Georgia; Arumugam, Prabhu; Patch, Christine; Rendon, Augusto; Bentley, David; Kingsley, Clare; A. Kosmicki, Jack; E. Horowitz, Julie; Baras, Aris; R. Abecasis, Goncalo; A. R. Ferreira, Manuel; Justice, Anne; Mirshahi, Tooraj; Oetjens, Matthew; J. Rader, Daniel; D. Ritchie, Marylyn; Verma, Anurag; A. Fowler, Tom; Shankar-Hari, Manu; Summers, Charlotte; Hinds, Charles; Horby, Peter; Ling, Lowell; McAuley, Danny; Montgomery, Hugh; J. M. Openshaw, Peter; Elliott, Paul; Walsh, Timothy; Tenesa, Albert; investigators, GenOMICC; co-investigators, GenOMICC; Kenneth Baillie, J.; Begg, Colin; Clohisey Hendry, Sara; Hinds, Charles; Horby, Peter; Knight, Julian; Ling, Lowell; Maslove, David; McAuley, Danny; Millar, Johnny; Montgomery, Hugh; Nichol, Alistair; J. M. Openshaw, Peter; C. Pereira, Alexandre; P. Ponting, Chris; Rowan, Kathy; G. Semple, Malcolm; Shankar-Hari, Manu; Summers, Charlotte; Walsh, Timothy; laboratory and data team, Management,; Aravindan, Latha; Armstrong, Ruth; Biggs, Heather; Boz, Ceilia; Brown, Adam; Clark, Richard; Coutts, Audrey; Coyle, Judy; Cullum, Louise; Das, Sukamal; Day, Nicky; Donnelly, Lorna; Duncan, Esther; Fawkes, Angie; Finernan, Paul; Head Fourman, Max; Furlong, Anita; Furniss, James; Gallagher, Bernadette; Gilchrist, Tammy; Golightly, Ailsa; Griffiths, Fiona; Hafezi, Katarzyna; Hamilton, Debbie; Hendry, Ross; Law, Andy; Law, Dawn; Law, Rachel; Law, Sarah; Lidstone-Scott, Rebecca; Macgillivray, Louise; Maclean, Alan; Mal, Hanning; McCafferty, Sarah; Mcmaster, Ellie; Meikle, Jen; C. Moore, Shona; Morrice, Kirstie; Murphy, Lee; Murphy, Sheena; Hellen, Mybaya; Oosthuyzen, Wilna; Zheng, Chenqing; Chen, Jiantao; Parkinson, Nick; Paterson, Trevor; Schon, Katherine; Stenhouse, Andrew; Das, Mihaela; Swets, Maaike; Szoor-McElhinney, Helen; Taneski, Filip; Turtle, Lance; Wackett, Tony; Ward, Mairi; Weaver, Jane; Wrobel, Nicola; Zechner, Marie; and St Thomas’ Hospital team, Guy’s; Arbane, Gill; Bociek, Aneta; Campos, Sara; Grau, Neus; Owen Jones, Tim; Lim, Rosario; Marotti, Martina; Ostermann, Marlies; Shankar-Hari, Manu; Whitton, Christopher; Health NHS Trust team, Barts; Alldis, Zoe; Astin-Chamberlain, Raine; Bibi, Fatima; Biddle, Jack; Blow, Sarah; Bolton, Matthew; Borra, Catherine; Bowles, Ruth; Burton, Maudrian; Choudhury, Yasmin; Collier, David; Cox, Amber; Easthope, Amy; Ebano, Patrizia; Fotiadis, Stavros; Gurasashvili, Jana; Halls, Rosslyn; Hartridge, Pippa; Kallon, Delordson; Kassam, Jamila; Lancoma-Malcolm, Ivone; Matharu, Maninderpal; May, Peter; Mitchelmore, Oliver; Newman, Tabitha; Patel, Mital; Pheby, Jane; Pinzuti, Irene; Prime, Zoe; Prysyazhna, Oleksandra; Shiel, Julian; Taylor, Melanie; Tierney, Carey; Wood, Suzanne; Zak, Anne; Zongo, Olivier; Cook University Hospital team, James; Bonner, Stephen; Hugill, Keith; Jones, Jessica; Liggett, Steven; Headlam, Evie; Stoke University Hospital team, Royal; Bandla, Nageswar; Gellamucho, Minnie

doi:10.1038/s41586-022-04576-6

Public

Whole-genome sequencing reveals host factors underlying critical COVID-19

Shared by NobleBlocks on Mar 7, 2022 • 12:00 AM UTC

Authors:

Athanasios Kousathanas

Erola Pairo-Castineira

Konrad Rawlik

Abstract

Abstract Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care 1 or hospitalization 2–4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the com...

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