Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

Liu, David; Schilling, Bastian; Liu, Derek; Sucker, Antje; Livingstone, Elisabeth; Jerby-Arnon, Livnat; Zimmer, Lisa; Gutzmer, Ralf; Satzger, Imke; Loquai, Carmen; Grabbe, Stephan; Vokes, Natalie; A. Margolis, Claire; Conway, Jake; Xiao He, Meng; Elmarakeby, Haitham; Dietlein, Felix; Miao, Diana; Tracy, Adam; Gogas, Helen; M. Goldinger, Simone; Utikal, Jochen; U. Blank, Christian; Rauschenberg, Ricarda; von Bubnoff, Dagmar; Krackhardt, Angela; Weide, Benjamin; Haferkamp, Sebastian; Kiecker, Felix; Izar, Ben; Garraway, Levi; Regev, Aviv; Flaherty, Keith; Paschen, Annette; M. Van Allen, Eliezer; Schadendorf, Dirk

doi:10.1038/s41591-019-0654-5

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Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

Shared by NobleBlocks on Dec 1, 2019 • 12:00 AM UTC

Authors:

David Liu

Bastian Schilling

Derek Liu

Abstract

Abstract Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma ( n = 144) treated with anti-PD1 ICB, with whol...

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