Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe

Champy, Pierre; U. Höglinger, Günter; Féger, Jean; Gleye, Christophe; Hocquemiller, Reynald; Laurens, Alain; Guérineau, Vincent; Laprévote, Olivier; Medja, Fadia; Lombès, Anne; P. Michel, Patrick; Lannuzel, Annie; C. Hirsch, Etienne; Ruberg, Merle

doi:10.1046/j.1471-4159.2003.02138.x

Public

Annonacin, a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical parkinsonism in Guadeloupe

Shared by NobleBlocks on Nov 28, 2003 • 12:00 AM UTC

Authors:

Pierre Champy

Günter U. Höglinger

Jean Féger

Abstract

Abstract In Guadeloupe, epidemiological data have linked atypical parkinsonism with fruit and herbal teas from plants of the Annonaceae family, particularly Annona muricata . These plants contain a class of powerful, lipophilic complex I inhibitors, the annonaceous acetogenins. To determine the neur...

Discussions