Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.

V, Ratziu; SA, Harrison; S, Francque; P, Bedossa; P, Lehert; L, Serfaty; M, Romero-Gomez; J, Boursier; M, Abdelmalek; S, Caldwell; J, Drenth; QM, Anstee; D, Hum; R, Hanf; A, Roudot; S, Megnien; B, Staels; A, Sanyal

doi:10.1053/j.gastro.2016.01.038

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Elafibranor, an Agonist of the Peroxisome Proliferator-Activated Receptor-α and -δ, Induces Resolution of Nonalcoholic Steatohepatitis Without Fibrosis Worsening.

Shared by NobleBlocks on Feb 11, 2016 • 12:00 AM UTC

Authors:

Ratziu V

Harrison SA

Francque S

Abstract

Background & aims Elafibranor is an agonist of the peroxisome proliferator-activated receptor-α and peroxisome proliferator-activated receptor-δ. Elafibranor improves insulin sensitivity, glucose homeostasis, and lipid metabolism and reduces inflammation. We assessed the safety and efficacy of elafi...

Subject

Fatty liver

Nafld

Ppara

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