HLA-A★3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

McCormack, M.; Alfirevic, A.; Bourgeois, Stephane; Farrell, J.; Kasperavičiūtė, Dalia; Carrington, M.; Sills, G.; Marson, T.; Jia, Xiaoming; D. Bakker, P.; Chinthapalli, K.; Molokhia, M.; R. Johnson, Michael; O’Connor, G.; Chaila, E.; Alhusaini, S.; Shianna, K.; Radtke, R.; Heinzen, E.; Walley, N.; Pandolfo, M.; Pichler, W.; Park, B.; Depondt, C.; Sisodiya, S.; Goldstein, D.; Deloukas, P.; Delanty, N.; Delanty, N.; Cavalleri, G.; Pirmohamed, M.

doi:10.1056/NEJMoa1013297

Public

HLA-A★3101 and Carbamazepine-Induced Hypersensitivity Reactions in Europeans

Shared by NobleBlocks on Mar 24, 2011 • 12:00 AM UTC

Authors:

M. McCormack

A. Alfirevic

Stephane Bourgeois

Abstract

BACKGROUND Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B★1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens–Johnson syndrome and toxic epidermal necrolysis (SJS–TEN...

Subject

Medicine

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