Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

Corey, L.; Gilbert, P.; Juraska, M.; Montefiori, D.; Morris, L.; Karuna, S.; Edupuganti, S.; Mgodi, N.; C. deCamp, Allan; Rudnicki, Erika; Huang, Yunda; Gonzales, P.; Cabello, R.; Orrell, C.; Lama, J.; Laher, F.; Lazarus, E.; Sanchez, Jorge; Frank, I.; Hinojosa, J.; Sobieszczyk, M.; Marshall, Kyle; Mukwekwerere, P.; Makhema, J.; Baden, L.; Mullins, J.; Williamson, C.; Hural, J.; McElrath, M.; Bentley, Carter; Takuva, Simbarashe; M Gomez Lorenzo, Margarita; Burns, D.; Espy, Nicole; Randhawa, A.; Kochar, Nidhi; Piwowar-Manning, E.; Donnell, D.; Sista, N.; Andrew, P.; Kublin, J.; Gray, G.; Ledgerwood, J.; Mascola, J.; Cohen, M.

doi:10.1056/NEJMoa2031738

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Two Randomized Trials of Neutralizing Antibodies to Prevent HIV-1 Acquisition

Shared by NobleBlocks on Mar 18, 2021 • 12:00 AM UTC

Authors:

L. Corey

P. Gilbert

M. Juraska

Abstract

BACKGROUND Whether a broadly neutralizing antibody (bnAb) can be used to prevent human immunodeficiency virus type 1 (HIV-1) acquisition is unclear. METHODS We enrolled at-risk cisgender men and transgender persons in the Americas and Europe in the HVTN 704/HPTN 085 trial and at-risk women in sub-Sa...

Subject

Medicine

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