Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Negative Chronic Hepatitis B

J. Hadziyannis, Stephanos; C. Tassopoulos, Nicolaos; Jenny Heathcote, E.; Chang, Ting‐Tsung; Kitis, G.; Rizzetto, Mario; Marcellin, Patrick; Gee Lim, Seng; Goodman, Zachary; Wulfsohn, Michael; Xiong, Shelly; Fry, John; Brosgart, Carol

doi:10.1056/NEJMOA021812

Public

Adefovir Dipivoxil for the Treatment of Hepatitis B e Antigen–Negative Chronic Hepatitis B

Shared by NobleBlocks on Feb 26, 2003 • 12:00 AM UTC

Authors:

Stephanos J. Hadziyannis

Nicolaos C. Tassopoulos

E. Jenny Heathcote

Abstract

BACKGROUND: Adefovir dipivoxil, a nucleotide analogue, demonstrated clinically significant antiviral activity in patients with chronic hepatitis B in phase 1 and 2 clinical trials. METHODS: We randomly assigned 185 patients with chronic hepatitis B who were negative for hepatitis B e antigen (HBeAg)...

Subject

Adefovir

Medicine

Gastroenterology

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