A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis.

Belfort, R.; Harrison, S.; A. Brown, K.; Darland, Celia; Finch, J.; Hardies, Jean; Balas, B.; Gastaldelli, A.; Tio, F.; P Pulcini, Joseph; Berria, R.; Z. Ma, Jennie; Dwivedi, S.; Havranek, R.; Fincke, C.; DeFronzo, R.; Bannayan, G.; Schenker, S.; Cusi, K.

doi:10.1056/NEJMOA060326

Public

A Placebo-Controlled Trial of Pioglitazone in Subjects with Nonalcoholic Steatohepatitis

Shared by NobleBlocks on Nov 29, 2006 • 12:00 AM UTC

Authors:

Renata Belfort

Stephen A. Harrison

Kenneth Brown

Abstract

BACKGROUND: No pharmacologic therapy has conclusively proved to be effective for the treatment of nonalcoholic steatohepatitis, which is characterized by insulin resistance, steatosis, and necroinflammation with or without centrilobular fibrosis. Pioglitazone is a thiazolidinedione that ameliorates ...

Subject

Pioglitazone

Internal medicine

Medicine

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