Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.

Van Cutsem, Eric; Köhne, Claus-Henning; Hitre, Erika; Zaluski, Jerzy; Chang Chien, Chung-Rong; Makhson, Anatoly; D'Haens, Geert; Pintér, Tamás; Lim, Robert; Bodoky, György; Kyung Roh, Jae; Folprecht, Gunnar; Ruff, Paul; Stroh, Christopher; Tejpar, Sabine; Schlichting, Michael; Nippgen, Johannes; Rougier, Philippe

doi:10.1056/NEJMoa0805019

Public

Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer.

Shared by NobleBlocks on Apr 2, 2009 • 12:00 AM UTC

Authors:

Eric Van Cutsem

Claus-Henning Köhne

Erika Hitre

Abstract

BACKGROUND: We investigated the efficacy of cetuximab plus irinotecan, fluorouracil, and leucovorin (FOLFIRI) as first-line treatment for metastatic colorectal cancer and sought associations between the mutation status of the KRAS gene in tumors and clinical response to cetuximab. METHODS: We random...

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