Screening for epidermal growth factor receptor mutations in lung cancer.

Rosell, Rafael; Moran, Teresa; Queralt, Cristina; Porta, Rut; Cardenal, Felipe; Camps, Carlos; Majem, Margarita; Lopez-Vivanco, Guillermo; Isla, Dolores; Provencio, Mariano; Insa, Amelia; Massuti, Bartomeu; Luis Gonzalez-Larriba, Jose; Paz-Ares, Luis; Bover, Isabel; Garcia-Campelo, Rosario; Angel Moreno, Miguel; Catot, Silvia; Rolfo, Christian; Reguart, Noemi; Palmero, Ramon; Miguel Sánchez, José; Bastus, Roman; Mayo, Clara; Bertran-Alamillo, Jordi; Angel Molina, Miguel; Javier Sanchez, Jose; Taron, Miquel; Lung Cancer Group, Spanish

doi:10.1056/NEJMoa0904554

Public

Screening for epidermal growth factor receptor mutations in lung cancer.

Shared by NobleBlocks on Sep 3, 2009 • 12:00 AM UTC

Authors:

Rafael Rosell

Teresa Moran

Cristina Queralt

Abstract

BACKGROUND: Activating mutations in the epidermal growth factor receptor gene (EGFR) confer hypersensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib in patients with advanced non-small-cell lung cancer. We evaluated the feasibility of large-scale screening for EGFR mutations in suc...

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