HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

McCormack, Mark; Alfirevic, Ana; Bourgeois, Stephane; J Farrell, John; Kasperavičiūtė, Dalia; Carrington, Mary; J Sills, Graeme; Marson, Tony; Jia, Xiaoming; I W de Bakker, Paul; Chinthapalli, Krishna; Molokhia, Mariam; R Johnson, Michael; D O'Connor, Gerard; Chaila, Elijah; Alhusaini, Saud; V Shianna, Kevin; A Radtke, Rodney; L Heinzen, Erin; Walley, Nicole; Pandolfo, Massimo; Pichler, Werner; Kevin Park, B; Depondt, Chantal; M Sisodiya, Sanjay; B Goldstein, David; Deloukas, Panos; Delanty, Norman; L Cavalleri, Gianpiero; Pirmohamed, Munir

doi:10.1056/NEJMoa1013297

Public

HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans.

Shared by NobleBlocks on Mar 24, 2011 • 12:00 AM UTC

Authors:

Mark McCormack

Ana Alfirevic

Stephane Bourgeois

Abstract

BACKGROUND: Carbamazepine causes various forms of hypersensitivity reactions, ranging from maculopapular exanthema to severe blistering reactions. The HLA-B*1502 allele has been shown to be strongly correlated with carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TE...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!