Pembrolizumab for the treatment of non-small-cell lung cancer.

B Garon, Edward; A Rizvi, Naiyer; Hui, Rina; Leighl, Natasha; S Balmanoukian, Ani; Paul Eder, Joseph; Patnaik, Amita; Aggarwal, Charu; Gubens, Matthew; Horn, Leora; Carcereny, Enric; Ahn, Myung-Ju; Felip, Enriqueta; Lee, Jong-Seok; D Hellmann, Matthew; Hamid, Omid; W Goldman, Jonathan; Soria, Jean-Charles; Dolled-Filhart, Marisa; Z Rutledge, Ruth; Zhang, Jin; K Lunceford, Jared; Rangwala, Reshma; M Lubiniecki, Gregory; Roach, Charlotte; Emancipator, Kenneth; Gandhi, Leena; Investigators, KEYNOTE-001

doi:10.1056/NEJMoa1501824

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Pembrolizumab for the treatment of non-small-cell lung cancer.

Shared by NobleBlocks on May 21, 2015 • 12:00 AM UTC

Authors:

Edward B Garon

Naiyer A Rizvi

Rina Hui

Abstract

BACKGROUND: We assessed the efficacy and safety of programmed cell death 1 (PD-1) inhibition with pembrolizumab in patients with advanced non-small-cell lung cancer enrolled in a phase 1 study. We also sought to define and validate an expression level of the PD-1 ligand 1 (PD-L1) that is associated ...

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