Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.

Paganoni, S.; Macklin, E.; Hendrix, S.; Berry, J.; A. Elliott, Michael; Maiser, S.; Karam, C.; Caress, J.; Owegi, M.; Quick, Adam; Wymer, J.; A. Goutman, Stephen; Heitzman, Daragh; Heiman-Patterson, T.; Jackson, C.; Quinn, C.; Rothstein, J.; Kasarskis, E.; Katz, J.; Jenkins, Liberty; Ladha, S.; Miller, T.; Scelsa, S.; Vu, Tuan-Ha; N. Fournier, Christina; Glass, J.; Johnson, Kristina; Swenson, A.; A. Goyal, Namita; L. Pattee, Gary; Andres, P.; Babu, Suma; K Chase, Marianne; Dagostino, D.; Dickson, S.; Ellison, N.; Hall, Meghan; Hendrix, K.; Kittle, Gale; M. McGovern, Michelle; Ostrow, Joseph; Pothier, Lindsay; Randall, Rebecca; Shefner, J.; Sherman, A.; Tustison, E.; Vigneswaran, P.; Walker, Jason; Yu, Hong; Chan, James; Wittes, J.; Cohen, J.; Klee, J.; Leslie, K.; Tanzi, R.; Gilbert, Walter; Yeramian, P.; Schoenfeld, D.; Cudkowicz, M.

doi:10.1056/NEJMoa1916945

Public

Trial of Sodium Phenylbutyrate-Taurursodiol for Amyotrophic Lateral Sclerosis.

Shared by NobleBlocks on Sep 2, 2020 • 12:00 AM UTC

Authors:

S. Paganoni

E. Macklin

S. Hendrix

Abstract

BACKGROUND Sodium phenylbutyrate and taurursodiol have been found to reduce neuronal death in experimental models. The efficacy and safety of a combination of the two compounds in persons with amyotrophic lateral sclerosis (ALS) are not known. METHODS In this multicenter, randomized, double-blind tr...

Subject

Medicine

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