Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.

Powles, Thomas; Hoon Park, Se; Voog, Eric; Caserta, Claudia; P Valderrama, Begoña; Gurney, Howard; Kalofonos, Haralabos; Radulović, Siniša; Demey, Wim; Ullén, Anders; Loriot, Yohann; S Sridhar, Srikala; Tsuchiya, Norihiko; Kopyltsov, Evgeny; N Sternberg, Cora; Bellmunt, Joaquim; B Aragon-Ching, Jeanny; P Petrylak, Daniel; Laliberte, Robert; Wang, Jing; Huang, Bo; Davis, Craig; Fowst, Camilla; Costa, Nuno; A Blake-Haskins, John; di Pietro, Alessandra; Grivas, Petros

doi:10.1056/NEJMoa2002788

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Avelumab Maintenance Therapy for Advanced or Metastatic Urothelial Carcinoma.

Shared by NobleBlocks on Sep 24, 2020 • 12:00 AM UTC

Authors:

Thomas Powles

Se Hoon Park

Eric Voog

Abstract

BACKGROUND: Platinum-based chemotherapy is standard-of-care first-line treatment for advanced urothelial carcinoma. However, progression-free survival and overall survival are limited by chemotherapy resistance. METHODS: In a phase 3 trial, we randomly assigned patients with unresectable locally adv...

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