Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.

D DiNardo, Courtney; A Jonas, Brian; Pullarkat, Vinod; J Thirman, Michael; S Garcia, Jacqueline; H Wei, Andrew; Konopleva, Marina; Döhner, Hartmut; Letai, Anthony; Fenaux, Pierre; Koller, Elizabeth; Havelange, Violaine; Leber, Brian; Esteve, Jordi; Wang, Jianxiang; Pejsa, Vlatko; Hájek, Roman; Porkka, Kimmo; Illés, Árpád; Lavie, David; M Lemoli, Roberto; Yamamoto, Kazuhito; Yoon, Sung-Soo; Jang, Jun-Ho; Yeh, Su-Peng; Turgut, Mehmet; Hong, Wan-Jen; Zhou, Ying; Potluri, Jalaja; W Pratz, Keith

doi:10.1056/NEJMoa2012971

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Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia.

Shared by NobleBlocks on Aug 13, 2020 • 12:00 AM UTC

Authors:

Courtney D DiNardo

Brian A Jonas

Vinod Pullarkat

Abstract

BACKGROUND: Older patients with acute myeloid leukemia (AML) have a dismal prognosis, even after treatment with a hypomethylating agent. Azacitidine added to venetoclax had promising efficacy in a previous phase 1b study. METHODS: We randomly assigned previously untreated patients with confirmed AML...

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