Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

PE, Lipsky; der Heijde DM, van; Clair EW, St; DE, Furst; FC, Breedveld; JR, Kalden; JS, Smolen; M, Weisman; P, Emery; M, Feldmann; GR, Harriman; RN, Maini

doi:10.1056/nejm200011303432202

Public

Infliximab and methotrexate in the treatment of rheumatoid arthritis. Anti-Tumor Necrosis Factor Trial in Rheumatoid Arthritis with Concomitant Therapy Study Group.

Shared by NobleBlocks on Nov 1, 2000 • 12:00 AM UTC

Authors:

Lipsky PE

van der Heijde DM

St Clair EW

Abstract

Background Neutralization of tumor necrosis factor a (TNF-alpha) for three to six months reduces the symptoms and signs of rheumatoid arthritis. However, the capacity of this approach to effect a more sustained benefit and its effect on joint damage are not known.Methods We treated 428 patients who ...

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