Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.

P, Marcellin; TT, Chang; SG, Lim; MJ, Tong; W, Sievert; ML, Shiffman; L, Jeffers; Z, Goodman; MS, Wulfsohn; S, Xiong; J, Fry; CL, Brosgart

doi:10.1056/nejmoa020681

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Adefovir dipivoxil for the treatment of hepatitis B e antigen-positive chronic hepatitis B.

Shared by NobleBlocks on Feb 1, 2003 • 12:00 AM UTC

Authors:

Marcellin P

Chang TT

Lim SG

Abstract

Background In preclinical and phase 2 studies, adefovir dipivoxil demonstrated potent activity against hepatitis B virus (HBV), including lamivudine-resistant strains.Methods We randomly assigned 515 patients with chronic hepatitis B who were positive for hepatitis B e antigen (HBeAg) to receive 10 ...

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