Effective treatment of severe COVID-19 patients with tocilizumab

Xu, Xiaoling; Han, Mingfeng; Li, Tiantian; Sun, Wei; Wang, Dongsheng; Fu, Binqing; Zhou, Yonggang; Zheng, Xiaohu; Yang, Yun; Li, Xiuyong; Zhang, Xiaohua; Pan, Aijun; Wei, Haiming

doi:10.1073/pnas.2005615117

Public

Effective treatment of severe COVID-19 patients with tocilizumab

Shared by NobleBlocks on Apr 28, 2020 • 12:00 AM UTC

Authors:

Xiaoling Xu

Mingfeng Han

Tiantian Li

Abstract

Significance In patients with coronavirus disease 2019, a large number of T lymphocytes and mononuclear macrophages are activated, producing cytokines such as interleukin-6 (IL-6), which bind to the IL-6 receptor on the target cells, causing the cytokine storm and severe inflammatory responses in lu...

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