Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.

TD, Warner; F, Giuliano; I, Vojnovic; A, Bukasa; JA, Mitchell; JR, Vane

doi:10.1073/pnas.96.13.7563

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Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis.

Shared by NobleBlocks on Jun 1, 1999 • 12:00 AM UTC

Authors:

Warner TD

Giuliano F

Vojnovic I

Abstract

The beneficial actions of nonsteroid anti-inflammatory drugs (NSAID) can be associated with inhibition of cyclo-oxygenase (COX)-2 whereas their harmful side effects are associated with inhibition of COX-1. Here we report data from two related assay systems, the human whole blood assay and a modified...

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