The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.

Tomida, Seita; Takata, Misaki; Hirata, Tetsuya; Nagae, Masamichi; Nakano, Miyako; Kizuka, Yasuhiko

doi:10.1074/jbc.RA120.013079

Public

The SH3 domain in the fucosyltransferase FUT8 controls FUT8 activity and localization and is essential for core fucosylation.

Shared by NobleBlocks on Jun 5, 2020 • 12:00 AM UTC

Authors:

Seita Tomida

Misaki Takata

Tetsuya Hirata

Abstract

Core fucose is an N-glycan structure synthesized by α1,6-fucosyltransferase 8 (FUT8) localized to the Golgi apparatus and critically regulates the functions of various glycoproteins. However, how FUT8 activity is regulated in cells remains largely unclear. At the luminal side and uncommon for Golgi ...

Subject

N-linked glycosylation

Src homology 3 domain (SH3 domain)

core fucosylation

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