Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

P. Diniz, L.; Carvalho Almeida, Juliana; Tortelli, Vanessa; Vargas Lopes, Charles; Setti-Perdigão, Pedro; Stipursky, J.; Kahn, S.; Romão, L.; de Miranda, J.; Alves‐Leon, S.; M. de Souza, Jorge; Castro, N.; Panizzutti, R.; Gomes, F.

doi:10.1074/jbc.M112.380824

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Astrocyte-induced Synaptogenesis Is Mediated by Transforming Growth Factor β Signaling through Modulation of d-Serine Levels in Cerebral Cortex Neurons

Shared by NobleBlocks on Oct 10, 2012 • 12:00 AM UTC

Authors:

L. P. Diniz

Juliana Carvalho Almeida

Vanessa Tortelli

Abstract

Background: Synapse formation and function is modulated by intrinsic and extrinsic non-autonomous factors. Results: Astrocytes induce synapse formation through TGF-β1 pathway. TGF-β1 synaptogenic property is dependent on d-serine signaling. Conclusion: TGF-β induces excitatory glutamatergic synapses...

Subject

Biology

Medicine

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