Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.

Umar, A.; Boland, C.; Terdiman, J.; Syngal, S.; de la Chapelle, A.; Rüschoff, J.; Fishel, R.; Lindor, N.; Burgart, L.; Hamelin, R.; Hamilton, S.; Hiatt, R.; Jass, J.; Lindblom, A.; Lynch, H.; Peltomaki, P.; Ramsey, S.; Rodriguez-Bigas, M.; Vasen, H.; Hawk, E.; Barrett, J.; Freedman, A.; Srivastava, S.

doi:10.1093/JNCI/DJH034

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Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability.

Shared by NobleBlocks on Feb 18, 2004 • 12:00 AM UTC

Authors:

A. Umar

C. Boland

J. Terdiman

Abstract

Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is a common autosomal dominant syndrome characterized by early age at onset, neoplastic lesions, and microsatellite instability (MSI). Because cancers with MSI account for approximately 15% of all colorectal cancers and...

Subject

Medicine

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