Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis.

E, Daugas; SA, Susin; N, Zamzami; KF, Ferri; T, Irinopoulou; N, Larochette; MC, Prévost; B, Leber; D, Andrews; J, Penninger; G, Kroemer

doi:10.1096/fasebj.14.5.729

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Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis.

Shared by NobleBlocks on Apr 1, 2000 • 12:00 AM UTC

Authors:

Daugas E

Susin SA

Zamzami N

Abstract

Apoptosis inducing factor (AIF) is a novel apoptotic effector protein that induces chromatin condensation and large-scale ( approximately 50 kbp) DNA fragmentation when added to purified nuclei in vitro. Confocal and electron microscopy reveal that, in normal cells, AIF is strictly confined to mitoc...

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