Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

W. Guarnieri, Joseph; Topper, Michael; Beigel, K.; Haltom, Jeffrey; Chadburn, A.; J. Frere, Justin; An, Julia; Cope, H.; Borczuk, A.; Sinha, Saloni; Lim, Christine; Kim, Jangkeun; Park, Jiwoon; Meydan, Cem; Foox, J.; Mozsary, C.; Bram, Y.; Richard, S.; Epsi, N.; S. Agan, Brianne; G Chenoweth, Josh; Simons, M.; Tribble, D.; Burgess, T.; L. Dalgard, Cliffton; Heise, M.; J. Moorman, Nathaniel; Baxter, V.; A. Madden, E.; Taft-Benz, S.; J. Anderson, Elizabeth; Sanders, Wes; J. Dickmander, Rebekah; A. Widjaja, Gabrielle; Janssen, Kevin; Lie, Timothy; G. Murdock, Deborah; Angelin, A.; S. Albrecht, Y.; Z Olali, Arnold; Cen, Zimu; M. Dybas, Joseph; Priebe, Waldemar; Emmett, M.; M. Best, Sonja; Johnson, Maya; S. Trovao, Nidia; B Clark, Kevin; Zaksas, V.; Meller, Rob; Grabham, Peter; Schisler, J.; Moraes-Vieira, P.; Pollett, S.; E. Mason, Christopher; Wurtele, E.; M. Taylor, Deanne; Schwartz, R.; Beheshti, Afshin; Wallace, D.; Baylin, S.B.

doi:10.1101/2023.10.08.561395

Public

Lethal COVID-19 Associates With RAAS-Induced Inflammation For Multiple Organ Damage Including Mediastinal Lymph Nodes

Shared by NobleBlocks on Oct 27, 2023 • 12:00 AM UTC

Authors:

Joseph W. Guarnieri

Michael Topper

K. Beigel

Abstract

Lethal COVID-19 outcomes are most often attributed to classic cytokine storm and attendant excessive immune signaling. We re-visit this question using RNA sequencing in nasopharyngeal and 40 autopsy samples from COVID-19-positive and negative individuals. In nasal swabs, the top 100 genes which sign...

Subject

Biology

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