Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

F, Magnotti; D, Chirita; S, Dalmon; A, Martin; P, Bronnec; J, Sousa; O, Helynck; W, Lee; D, Kastner; JJ, Chae; MF, McDermott; A, Belot; M, Popoff; P, Sève; S, Georgin-Lavialle; H, Munier-Lehmann; TA, Tran; ED, Langhe; C, Wouters; Y, Jamilloux; T, Henry

doi:10.1101/2021.10.29.466454

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Steroid hormone catabolites activate the pyrin inflammasome through a non-canonical mechanism

Shared by NobleBlocks on Oct 29, 2021 • 12:00 AM UTC

Authors:

Magnotti F

Chirita D

Dalmon S

Abstract

The pyrin inflammasome acts as a guard of RhoA GTPases and is central to immune defences against RhoA-manipulating pathogens. Pyrin activation proceeds in two steps. Yet, the second step is still poorly understood. Using cells constitutively activated for the pyrin step 1, a chemical screen identifi...

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