Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8(+) T cell receptor alpha repertoire following allogeneic transplantation.

CS, Link; A, Eugster; F, Heidenreich; E, Rücker-Braun; M, Schmiedgen; U, Oelschlägel; D, Kühn; S, Dietz; Y, Fuchs; A, Dahl; AM, Domingues; C, Klesse; M, Schmitz; G, Ehninger; M, Bornhäuser; J, Schetelig; E, Bonifacio

doi:10.1111/cei.12770

Public

Abundant cytomegalovirus (CMV) reactive clonotypes in the CD8(+) T cell receptor alpha repertoire following allogeneic transplantation.

Shared by NobleBlocks on Mar 8, 2016 • 12:00 AM UTC

Authors:

Link CS

Eugster A

Heidenreich F

Abstract

Allogeneic stem cell transplantation is potentially curative, but associated with post-transplantation complications, including cytomegalovirus (CMV) infections. An effective immune response requires T cells recognizing CMV epitopes via their T cell receptors (TCRs). Little is known about the TCR re...

Subject

CMV

Allogeneic transplantation

Next-generation Sequencing

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