The expansion of human T-bethighCD21low B cells is T cell dependent

Keller, Baerbel; Strohmeier, Valentina; Harder, Ina; Unger, S.; Payne, K.; Andrieux, G.; Boerries, M.; Tobias Felixberger, Peter; Landry, J.; Nieters, A.; Rensing-Ehl, A.; Salzer, U.; Frede, N.; Usadel, S.; Elling, R.; Speckmann, C.; Hainmann, I.; Ralph, E.; Gilmour, K.; W. J. Wentink, Marjolein; van der Burg, M.; Kuehn, H.; Rosenzweig, S.; Kölsch, U.; von Bernuth, H.; Kaiser-Labusch, P.; Gothe, F.; Hambleton, S.; Vlagea, A.; Garcia Garcia, Ana; Alsina, L.; Markelj, Gašper; Avčin, T.; Vasconcelos, Julia; Guedes, M.; Ding, Jing-Ya; Ku, Cheng-Lung; Shadur, Bella; Avery, D.; Venhoff, N.; Thiel, J.; Becker, H.; Erazo-Borrás, L.; M. Trujillo-Vargas, C.; Franco, J.; Fieschi, C.; Okada, S.; Gray, P.; Uzel, G.; Casanova, J.; Fliegauf, M.; Grimbacher, B.; Eibel, H.; Ehl, S.; Voll, R.; Rizzi, M.; Stepensky, P.; Beneš, V.; S. Ma, Cindy; Bossen, C.; Tangye, S.; Warnatz, K.

doi:10.1126/sciimmunol.abh0891

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The expansion of human T-bethighCD21low B cells is T cell dependent

Shared by NobleBlocks on Oct 8, 2021 • 12:00 AM UTC

Authors:

Baerbel Keller

Valentina Strohmeier

Ina Harder

Abstract

Description T cell–derived IFNγ and CD40L/IL-21R signals are crucial for the differentiation of human T-bethighCD21low B cells. The factors behind autoimmune B cells T-bethighCD21low B cells are expanded in various autoimmune disorders and infections, but it is unclear how these cells develop. Deter...

Subject

Medicine

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