EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Paez, J.; Jänne, P.; C. Lee, Jeffrey; I Tracy, Sean; Greulich, H.; Gabriel, S.; Herman, P.; Kaye, F.; Lindeman, N.; Boggon, T.; Naoki, K.; Sasaki, H.; Fujii, Y.; Eck, M.; Sellers, W.; Johnson, B.; Meyerson, M.

doi:10.1126/SCIENCE.1099314

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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

Shared by NobleBlocks on May 3, 2004 • 12:00 AM UTC

Authors:

J. Guillermo Paez

Pasi A. Jänne

Jeffrey C. Lee

Abstract

Receptor tyrosine kinase genes were sequenced in non-small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inh...

Subject

Gefitinib

Lung cancer

Epidermal growth factor receptor

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