A global protein kinase and phosphatase interaction network in yeast.

Breitkreutz, Ashton; Choi, Hyungwon; R Sharom, Jeffrey; Boucher, Lorrie; Neduva, Victor; Larsen, Brett; Lin, Zhen-Yuan; Breitkreutz, Bobby-Joe; Stark, Chris; Liu, Guomin; Ahn, Jessica; Dewar-Darch, Danielle; Reguly, Teresa; Tang, Xiaojing; Almeida, Ricardo; Steve Qin, Zhaohui; Pawson, Tony; Gingras, Anne-Claude; I Nesvizhskii, Alexey; Tyers, Mike

doi:10.1126/science.1176495

Public

A global protein kinase and phosphatase interaction network in yeast.

Shared by NobleBlocks on May 21, 2010 • 12:00 AM UTC

Authors:

Ashton Breitkreutz

Hyungwon Choi

Jeffrey R Sharom

Abstract

The interactions of protein kinases and phosphatases with their regulatory subunits and substrates underpin cellular regulation. We identified a kinase and phosphatase interaction (KPI) network of 1844 interactions in budding yeast by mass spectrometric analysis of protein complexes. The KPI network...

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