A Defective HSV-1 Vector Expresses <i>Escherichia coli</i> β-Galactosidase in Cultured Peripheral Neurons

I. Geller, Alfred; O. Breakefield, Xandra

doi:10.1126/science.2843986

Public

A Defective HSV-1 Vector Expresses Escherichia coli β-Galactosidase in Cultured Peripheral Neurons

Shared by NobleBlocks on Sep 23, 1988 • 12:00 AM UTC

Authors:

Alfred I. Geller

Xandra O. Breakefield

Abstract

A defective herpes simplex virus 1 (HSV-1) vector, pHSVlac, has been developed that contains a transcription unit that places the Escherichia coli lacZ gene under the control of the HSV-1 immediate early 4/5 promoter. The vector pHSVlac was propagated with the HSV-1 temperature-sensitive mutant ts K...

Subject

Herpes simplex virus

Escherichia coli

Biology

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