Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Bastard, Paul; B. Rosen, Lindsey; Zhang, Qian; Michailidis, Eleftherios; Hoffmann, Hans-Heinrich; Zhang, Yu; Dorgham, Karim; Philippot, Quentin; Rosain, Jérémie; Béziat, Vivien; Manry, Jérémy; Shaw, Elana; Haljasmägi, Liis; Peterson, Pärt; Lorenzo, Lazaro; Bizien, Lucy; Trouillet-Assant, Sophie; Dobbs, Kerry; Almeida de Jesus, Adriana; Belot, Alexandre; Kallaste, Anne; Catherinot, Emilie; Tandjaoui-Lambiotte, Yacine; Le Pen, Jeremie; Kerner, Gaspard; Bigio, Benedetta; Seeleuthner, Yoann; Yang, Rui; Bolze, Alexandre; N. Spaan, András; M. Delmonte, Ottavia; S. Abers, Michael; Aiuti, Alessandro; Casari, Giorgio; Lampasona, Vito; Piemonti, Lorenzo; Ciceri, Fabio; Bilguvar, Kaya; P. Lifton, Richard; Vasse, Marc; M. Smadja, David; Migaud, Mélanie; Hadjadj, Jérome; Terrier, Benjamin; Duffy, Darragh; Quintana-Murci, Lluis; van de Beek, Diederik; Roussel, Lucie; C. Vinh, Donald; G. Tangye, Stuart; Haerynck, Filomeen; Dalmau, David; Martinez-Picado, Javier; Brodin, Petter; C. Nussenzweig, Michel; Boisson-Dupuis, Stéphanie; Rodríguez-Gallego, Carlos; Vogt, Guillaume; H. Mogensen, Trine; J. Oler, Andrew; Gu, Jingwen; D. Burbelo, Peter; I. Cohen, Jeffrey; Biondi, Andrea; Rachele Bettini, Laura; D'Angio, Mariella; Bonfanti, Paolo; Rossignol, Patrick; Mayaux, Julien; Rieux-Laucat, Frédéric; S. Husebye, Eystein; Fusco, Francesca; Valeria Ursini, Matilde; Imberti, Luisa; Sottini, Alessandra; Paghera, Simone; Quiros-Roldan, Eugenia; Rossi, Camillo; Castagnoli, Riccardo; Montagna, Daniela; Licari, Amelia; Luigi Marseglia, Gian; Duval, Xavier; Ghosn, Jade; Lab, HGID; Immune Response to COVID Group, NIAID-USUHS; Clinicians, COVID; Clinicians, COVID-STORM; COVID Group, Imagine; COVID Cohort Study Group, French; Milieu Intérieur Consortium, The; Cohort, CoV-Contact; UMC Covid-19 Biobank, Amsterdam; Human Genetic Effort, COVID; S. Tsang, John; Goldbach-Mansky, Raphaela; Kisand, Kai; S. Lionakis, Michail; Puel, Anne; Zhang, Shen-Ying; M. Holland, Steven; Gorochov, Guy; Jouanguy, Emmanuelle; M. Rice, Charles; Cobat, Aurélie; D. Notarangelo, Luigi; Abel, Laurent; C. Su, Helen; Casanova, Jean-Laurent; Augusto Arias, Andrés; Boisson, Bertrand; Boucherit, Soraya; Bustamante, Jacinta; Chbihi, Marwa; Chen, Jie; Chrabieh, Maya; Kochetkov, Tatiana; Le Voyer, Tom; Liu, Dana; Nemirovskaya, Yelena; Ogishi, Masato; Papandrea, Dominick; Patissier, Cécile; Rapaport, Franck; Roynard, Manon; Vladikine, Natasha; Woollett, Mark; Zhang, Peng; Kashyap, Anuj; Ding, Li; Bosticardo, Marita; Wang, Qinlu; Ochoa, Sebastian; Liu, Hui; D. Chauvin, Samuel; Stack, Michael; Koroleva, Galina; Bansal, Neha; L. Dalgard, Clifton; L. Snow, Andrew; Abad, Jorge; Aguilera-Albesa, Sergio; Metin Akcan, Ozge; Alavi Darazam, Ilad; C. Aldave, Juan; Alfonso Ramos, Miquel; Alireza Nadji, Seyed; Alkan, Gulsum; Allardet-Servent, Jerome; M. Allende, Luis; Alsina, Laia; Alyanakian, Marie-Alexandra; Amador-Borrero, Blanca; Amoura, Zahir; Antolí, Arnau; Arslan, Sevket; Assant, Sophie; Auguet, Terese; Azot, Axelle; Bajolle, Fanny; Baldolli, Aurélie; Ballester, Maite; Baris Feldman, Hagit; Barrou, Benoit; Beurton, Alexandra; Bilbao, Agurtzane; Blanchard-Rohner, Geraldine; Blanco, Ignacio; Blandinières, Adeline; Blazquez-Gamero, Daniel; Bloomfield, Marketa; Bolivar-Prados, Mireia; Borie, Raphael; A. Bousfiha, Ahmed; Bouvattier, Claire; Boyarchuk, Oksana; Rita P. Bueno, Maria; Bustamante, Jacinta; José Cáceres Agra, Juan; Calimli, Semra; Capra, Ruggero; Carrabba, Maria; Casasnovas, Carlos; Caseris, Marion; Castelle, Martin; Castelli, Francesco; Castillo de Vera, Martín; V. Castro, Mateus; Catherinot, Emilie; Chalumeau, Martin; Charbit, Bruno; P. Cheng, Matthew; Clavé, Père; Clotet, Bonaventura; Codina, Anna; Colkesen, Fatih; Colkesen, Fatma; Colobran, Roger; Comarmond, Cloé; G. Corsico, Angelo

doi:10.1126/science.abd4585

Public

Autoantibodies against type I IFNs in patients with life-threatening COVID-19

Shared by NobleBlocks on Oct 23, 2020 • 12:00 AM UTC

Authors:

Paul Bastard

Lindsey B. Rosen

Qian Zhang

Abstract

The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN respon...

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