The expansion of human T-bet<sup>high</sup>CD21<sup>low</sup> B cells is T cell dependent.

B, Keller; V, Strohmeier; I, Harder; S, Unger; KJ, Payne; G, Andrieux; M, Boerries; PT, Felixberger; JJM, Landry; A, Nieters; A, Rensing-Ehl; U, Salzer; N, Frede; S, Usadel; R, Elling; C, Speckmann; I, Hainmann; E, Ralph; K, Gilmour; MWJ, Wentink; der Burg M, van; HS, Kuehn; SD, Rosenzweig; U, Kölsch; Bernuth H, von; P, Kaiser-Labusch; F, Gothe; S, Hambleton; AD, Vlagea; Garcia A, Garcia; L, Alsina; G, Markelj; T, Avcin; J, Vasconcelos; M, Guedes; JY, Ding; CL, Ku; B, Shadur; DT, Avery; N, Venhoff; J, Thiel; H, Becker; L, Erazo-Borrás; CM, Trujillo-Vargas; JL, Franco; C, Fieschi; S, Okada; PE, Gray; G, Uzel; JL, Casanova; M, Fliegauf; B, Grimbacher; H, Eibel; S, Ehl; RE, Voll; M, Rizzi; P, Stepensky; V, Benes; CS, Ma; C, Bossen; SG, Tangye; K, Warnatz

doi:10.1126/sciimmunol.abh0891

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The expansion of human T-bethighCD21low B cells is T cell dependent.

Shared by NobleBlocks on Oct 8, 2021 • 12:00 AM UTC

Authors:

Keller B

Strohmeier V

Harder I

Abstract

Accumulation of human CD21low B cells in peripheral blood is a hallmark of chronic activation of the adaptive immune system in certain infections and autoimmune disorders. The molecular pathways underpinning the development, function, and fate of these CD21low B cells remain incompletely characteriz...

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