Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.

A, Yeste; MC, Takenaka; ID, Mascanfroni; M, Nadeau; JE, Kenison; B, Patel; AM, Tukpah; JA, Babon; M, DeNicola; SC, Kent; D, Pozo; FJ, Quintana

doi:10.1126/scisignal.aad0612

Public

Tolerogenic nanoparticles inhibit T cell-mediated autoimmunity through SOCS2.

Shared by NobleBlocks on Jun 21, 2016 • 12:00 AM UTC

Authors:

Yeste A

Takenaka MC

Mascanfroni ID

Abstract

Type 1 diabetes (T1D) is a T cell-dependent autoimmune disease that is characterized by the destruction of insulin-producing β cells in the pancreas. The administration to patients of ex vivo-differentiated FoxP3(+) regulatory T (Treg) cells or tolerogenic dendritic cells (DCs) that promote Treg cel...

Discussions