Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Bettegowda, Chetan; Sausen, Mark; J. Leary, Rebecca; Kinde, Isaac; Wang, Yuxuan; Agrawal, Nishant; R. Bartlett, Bjarne; Wang, Hao; Luber, Brandon; M. Alani, Rhoda; S. Antonarakis, Emmanuel; S. Azad, Nilofer; Bardelli, Alberto; Brem, Henry; L. Cameron, John; C. Lee, Clarence; A. Fecher, Leslie; L. Gallia, Gary; Gibbs, Peter; Le, Dung; L. Giuntoli, Robert; Goggins, Michael; D. Hogarty, Michael; Holdhoff, Matthias; Hong, Seung-Mo; Jiao, Yuchen; H. Juhl, Hartmut; J. Kim, Jenny; Siravegna, Giulia; A. Laheru, Daniel; Lauricella, Calogero; Lim, Michael; J. Lipson, Evan; Kazue Nagahashi Marie, Suely; J. Netto, George; S. Oliner, Kelly; Olivi, Alessandro; Olsson, Louise; J. Riggins, Gregory; Sartore-Bianchi, Andrea; Schmidt, Kerstin; Shih, le-Ming; Mieko Oba-Shinjo, Sueli; Siena, Salvatore; Theodorescu, Dan; Tie, Jeanne; T. Harkins, Timothy; Veronese, Silvio; Wang, Tian-Li; D. Weingart, Jon; L. Wolfgang, Christopher; D. Wood, Laura; Xing, Dongmei; H. Hruban, Ralph; Wu, Jian; J. Allen, Peter; Max Schmidt, C.; A. Choti, Michael; E. Velculescu, Victor; W. Kinzler, Kenneth; Vogelstein, Bert; Papadopoulos, Nickolas; A. Diaz, Luis

doi:10.1126/scitranslmed.3007094

Public

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Shared by NobleBlocks on Feb 19, 2014 • 12:00 AM UTC

Authors:

Chetan Bettegowda

Mark Sausen

Rebecca J. Leary

Abstract

Circulating tumor DNA can be used in a variety of clinical and investigational settings across tumor types and stages for screening, diagnosis, and identifying mutations responsible for therapeutic response and drug resistance.

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