Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers.

C Winter, Stuart; M Buffa, Francesca; Silva, Priyamal; Miller, Crispin; R Valentine, Helen; Turley, Helen; A Shah, Ketan; J Cox, Graham; J Corbridge, Rogan; J Homer, Jarrod; Musgrove, Brian; Slevin, Nick; Sloan, Philip; Price, Pat; M L West, Catharine; L Harris, Adrian

doi:10.1158/0008-5472.CAN-06-3322

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Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers.

Shared by NobleBlocks on Apr 1, 2007 • 12:00 AM UTC

Authors:

Stuart C Winter

Francesca M Buffa

Priyamal Silva

Abstract

Affymetrix U133plus2 GeneChips were used to profile 59 head and neck squamous cell cancers. A hypoxia metagene was obtained by analysis of genes whose in vivo expression clustered with the expression of 10 well-known hypoxia-regulated genes (e.g., CA9, GLUT1, and VEGF). To minimize random aggregatio...

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