Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

Zhang, Keqiang; Chu, Kevin; Wu, Xiwei; Gao, Hanlin; Wang, Jinhui; Yuan, Yate-Ching; Loera, Sofia; Ho, Kimberley; Wang, Yafan; Chow, Warren; Un, Frank; Chu, Peiguo; Yen, Yun

doi:10.1158/0008-5472.CAN-12-2086

Public

Amplification of FRS2 and activation of FGFR/FRS2 signaling pathway in high-grade liposarcoma.

Shared by NobleBlocks on Feb 15, 2013 • 12:00 AM UTC

Authors:

Keqiang Zhang

Kevin Chu

Xiwei Wu

Abstract

Fibroblast growth factor (FGF) receptor (FGFR) substrate 2 (FRS2) is an adaptor protein that plays a critical role in FGFR signaling. FRS2 is located on chromosome 12q13-15 that is frequently amplified in liposarcomas. The significance of FRS2 and FGFR signaling in high-grade liposarcomas is unknown...

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