Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation–Positive Non–Small Cell Lung Cancer

Isomoto, K.; Haratani, K.; Hayashi, H.; Shimizu, S.; Tomida, S.; Niwa, T.; Yokoyama, T.; Fukuda, Y.; Chiba, Y.; Kato, R.; Tanizaki, J.; Tanaka, Kaoru; Takeda, M.; Ogura, T.; Ishida, T.; Ito, Akihiko; Nakagawa, K.

doi:10.1158/1078-0432.CCR-19-2027

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Impact of EGFR-TKI Treatment on the Tumor Immune Microenvironment in EGFR Mutation–Positive Non–Small Cell Lung Cancer

Shared by NobleBlocks on Jan 14, 2020 • 12:00 AM UTC

Authors:

K. Isomoto

K. Haratani

H. Hayashi

Abstract

Purpose: The impact of EGFR tyrosine kinase inhibitors (TKI) on the tumor immune microenvironment (TME) in non–small cell lung cancer (NSCLC) is unclear. Experimental Design: We retrospectively identified 138 patients with EGFR-mutated NSCLC who underwent rebiopsy after progression during EGFR-TKI t...

Subject

Medicine

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