Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer.

NJ, Neill; S, Satpathy; K, Krug; JK, Meena; Babu N, Ramesh; C, Calderon; D, Reed; MJ, Weber; LE, Dobrolecki; A, Lewis; C, Sallas; M, Anurag; KR, Holloway; C, Huang; S, Vasaikar; MF, Cardenas; BJ, Kim; DW, Chan; SC, Avanessian; S, Tyagi; M, Orellana; S, Mao; H, Li; F, Gong; SJ, Kurley; KL, Meerbrey; CM, Olson; A, Nair; T, Sun; HC, Chung; EA, Bowling; JH, Wang; P, Zhang; P, Xiao; D, Yang; F, Stossi; MC, Polley; AB, Saltzman; F, Mundt; DR, Mani; MA, Gillette; SG, Hilsenbeck; G, Miles; C, Gutierrez; CK, Osborne; CY, Lin; NS, Gray; J, Sun; DA, Wheeler; CM, Perou; A, Malovannaya; MT, Lewis; B, Zhang; MJ, Ellis; SA, Carr; TF, Westbrook

doi:10.1158/2159-8290.cd-23-1173

Public

Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer.

Shared by NobleBlocks on Nov 1, 2025 • 12:00 AM UTC

Authors:

Neill NJ

Satpathy S

Krug K

Abstract

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with few effective targeted therapies. Taxanes and other microtubule-targeting agents (MTA) are first-line chemotherapies for TNBC; however, the molecular mechanisms that underlie TNBC taxane sensitivity are largely unkno...

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