Acinetobacter Baumannii Secreted Protease CpaA Inhibits Factor XII-Mediated Bradykinin Generation and Neutrophil Activation

Background. Coagulation factor XII (FXII) is best known for its roles in the contact and kallikrein-kinin pathways. FXII is converted to its active enzyme (FXIIa) by plasma kallikrein or by its unique ability to autoactivate on bacterial or other biologic surfaces. In vivo, FXIIa initiates the intri... View More