Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method.

Zhang, Jianhua; Klos, Matthew; F Wilson, Gisela; M Herman, Amanda; Lian, Xiaojun; K Raval, Kunil; R Barron, Matthew; Hou, Luqia; G Soerens, Andrew; Yu, Junying; P Palecek, Sean; E Lyons, Gary; A Thomson, James; J Herron, Todd; Jalife, José; J Kamp, Timothy

doi:10.1161/CIRCRESAHA.112.273144

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Extracellular matrix promotes highly efficient cardiac differentiation of human pluripotent stem cells: the matrix sandwich method.

Shared by NobleBlocks on Oct 12, 2012 • 12:00 AM UTC

Authors:

Jianhua Zhang

Matthew Klos

Gisela F Wilson

Abstract

RATIONALE: Cardiomyocytes (CMs) differentiated from human pluripotent stem cells (PSCs) are increasingly being used for cardiovascular research, including disease modeling, and hold promise for clinical applications. Current cardiac differentiation protocols exhibit variable success across different...

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