Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

Grimwade, David; K. Hills, Robert; V. Moorman, Anthony; Walker, Helen; Chatters, Stephen; H. Goldstone, Anthony; Wheatley, Keith; J. Harrison, Christine; K. Burnett, Alan; behalf of the National Cancer Research Institute Adult Leukaemia Working Group, on

doi:10.1182/blood-2009-11-254441

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Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials

Shared by NobleBlocks on Jul 22, 2010 • 12:00 AM UTC

Authors:

David Grimwade

Robert K. Hills

Anthony V. Moorman

Abstract

Abstract Diagnostic karyotype provides the framework for risk-stratification schemes in acute myeloid leukemia (AML); however, the prognostic significance of many rare recurring cytogenetic abnormalities remains uncertain. We studied the outcomes of 5876 patients (16-59 years of age) who were classi...

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