APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Tai, Yu-Tzu; Acharya, Chirag; An, Gang; Moschetta, Michele; Y. Zhong, Mike; Feng, Xiaoyan; Cea, Michele; Cagnetta, Antonia; Wen, Kenneth; van Eenennaam, Hans; van Elsas, Andrea; Qiu, Lugui; Richardson, Paul; Munshi, Nikhil; C. Anderson, Kenneth

doi:10.1182/blood-2016-01-691162

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APRIL and BCMA promote human multiple myeloma growth and immunosuppression in the bone marrow microenvironment

Shared by NobleBlocks on Jun 23, 2016 • 12:00 AM UTC

Authors:

Yu-Tzu Tai

Chirag Acharya

Gang An

Abstract

Key Points APRIL/BCMA activation promotes MM proliferation, survival, and immunosuppression in vitro and in vivo. Targeting the APRIL/BCMA pathway represents a promising mechanism-based immunotherapy to target MM and overcome drug resistance.

Discussions