The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials.

PD, Kottaridis; RE, Gale; ME, Frew; G, Harrison; SE, Langabeer; AA, Belton; H, Walker; K, Wheatley; DT, Bowen; AK, Burnett; AH, Goldstone; DC, Linch

doi:10.1182/blood.v98.6.1752

Public

The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials.

Shared by NobleBlocks on Sep 1, 2001 • 12:00 AM UTC

Authors:

Kottaridis PD

Gale RE

Frew ME

Abstract

In acute myeloid leukemia (AML), further prognostic determinants are required in addition to cytogenetics to predict patients at increased risk of relapse. Recent studies have indicated that an internal tandem duplication (ITD) in the FLT3 gene may adversely affect clinical outcome. This study evalu...

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