Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice

Zhao, Hongwei; Zhang, Hong; Wu, Hui; Li, Hui; Liu, Lei; Guo, Jian; Li, Chenyang; Shih, D.; Zhang, Xiaolan

doi:10.1186/1471-230X-12-57

Public

Protective role of 1,25(OH)2vitamin D3 in the mucosal injury and epithelial barrier disruption in DSS-induced acute colitis in mice

Shared by NobleBlocks on May 30, 2012 • 12:00 AM UTC

Authors:

Hongwei Zhao

Hong Zhang

Hui Wu

Abstract

BackgroundIntestinal hyper-permeability plays a critical role in the etiopathogenesis of inflammatory bowel disease (IBD) by affecting the penetration of pathogens, toxic compounds and macromolecules. 1,25-dihydroxyvitamin D3 [1,25(OH)2D3], the active form of vitamin D, has been shown to be an impor...

Subject

Medicine

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