NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE trial).

A, Brouquet; JB, Bachet; F, Huguet; M, Karoui; P, Artru; C, Sabbagh; JH, Lefèvre; D, Vernerey; C, Mariette; E, Vicaut; S, Benoist

doi:10.1186/s12885-020-06968-1

Public

NORAD01-GRECCAR16 multicenter phase III non-inferiority randomized trial comparing preoperative modified FOLFIRINOX without irradiation to radiochemotherapy for resectable locally advanced rectal cancer (intergroup FRENCH-GRECCAR- PRODIGE trial).

Shared by NobleBlocks on May 29, 2020 • 12:00 AM UTC

Authors:

Brouquet A

Bachet JB

Huguet F

Abstract

Background Preoperative radiochemotherapy (RCT) is recommended in France prior to total mesorectal excision in patients with mid or low locally advanced rectal cancer (LARC) (cT3/T4 and/or N+) because it has been shown to improve local control. Preoperative RCT has also disadvantages including the a...

Subject

Quality of life

Locally Advanced Rectal Cancer

Circumferential Resection Margin

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!