DNA methylation age of blood predicts all-cause mortality in later life

E Marioni, Riccardo; Shah, Sonia; F McRae, Allan; H Chen, Brian; Colicino, Elena; E Harris, Sarah; Gibson, Jude; K Henders, Anjali; Redmond, Paul; R Cox, Simon; Pattie, Alison; Corley, Janie; Murphy, Lee; G Martin, Nicholas; W Montgomery, Grant; P Feinberg, Andrew; Daniele Fallin, M; L Multhaup, Michael; E Jaffe, Andrew; Joehanes, Roby; Schwartz, Joel; C Just, Allan; L Lunetta, Kathryn; M Murabito, Joanne; M Starr, John; Horvath, Steve; A Baccarelli, Andrea; Levy, Daniel; M Visscher, Peter; R Wray, Naomi; J Deary, Ian

doi:10.1186/s13059-015-0584-6

Public

DNA methylation age of blood predicts all-cause mortality in later life

Shared by NobleBlocks on Jan 28, 2015 • 12:00 AM UTC

Authors:

Riccardo E Marioni

Sonia Shah

Allan F McRae

Abstract

Abstract Background DNA methylation levels change with age. Recent studies have identified biomarkers of chronological age based on DNA methylation levels. It is not yet known whether DNA methylation age captures aspects of biological age. Results Here we test whether differences between people’s ch...

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